Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC FRETS-VWF73 TFA | 97.4% | 9340.61 | 5 MG
FRETS-VWF73 TFA is a 73-amino-acid peptide that functions as a fluorogenic substrate for ADAMTS13 assay.
- 73-amino-acid peptide
- Fluorogenic substrate for ADAMTS13 assay
- Excitation at 340 nm
- Emission at 450 nm
Medchemexpress LLC Mambalgin 1 TFA | 95.7% | 6554.54 | 100 UG
Mambalgin 1 TFA is a selective ASIC1a inhibitor with IC50 values of 192 nM for human ASIC1a and 72 nM for the ASIC1a/1b dimer. It binds to closed/inactive channels and exhibits selectivity for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2, and Kv1.2 channels. It has been shown to increase the latency of withdrawal response in mouse tail-flick and paw-flick tests. This product is for research use only.
- Selective ASIC1a inhibitor
- Binds to closed/inactive channels
- Increases latency of withdrawal response in mouse tail-flick and paw-flick tests
- For research use only
Medchemexpress LLC Alvespimycin trifluoroacetate | 00-00-0 | MFCD08457919 | 99.0% | 730.77 g·mol⁻¹ | C34H49F3N4O10 | 25 MG
Alvespimycin trifluoroacetate (17-DMAG TFA) is the trifluoroacetic acid salt of a semisynthetic geldanamycin derivative that potently inhibits Hsp90. It binds Hsp90 in the low-nanomolar range and is used in cellular and biochemical studies to induce heat-shock response and promote degradation of Hsp90 client proteins, supporting research into proteostasis and targeted oncology pathways.
- Potent Hsp90 inhibition with reported EC50 ≈ 62 nM.
- Promotes Her2 degradation in cancer cell lines (EC50 8 nM in SKBR3, 46 nM in SKOV3).
- Induces Hsp70 expression in cell assays (EC50 4 nM in SKBR3, 14 nM in SKOV3).
- High purity (>98.9%) suitable for in vitro studies.
- Available in small research pack sizes, including 25 MG.
Medchemexpress LLC Ebiratide TFA | 99.0% | 996.23 | 5 MG
Ebiratide TFA (HOE-427) is an ACTH 4-9 derivative that acts directly on the central nervous system and shows memory-enhancing effects. It increases acetylcholine (ACh) metabolism in the rat brain. Ebiratide TFA has neuroprotective efficacy in mice models with electroconvulsive shock and Scopolamine-induced memory impairment, demonstrating anti-amnestic efficacy.
- ACTH 4-9 derivative.
- Acts directly on the central nervous system.
- Exhibits memory-enhancing efficacy.
- Enhances acetylcholine (ACh) metabolism in rat brain.
- Exhibits neuroprotective and anti-amnestic efficacy in animal models.
Medchemexpress LLC L-Phenylalaninamide, 4-(methylsulfonyl)-L-2-aminobutanoyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-D-lysyl-N-(8-aminooctyl)- (TFA) | 99.0% | 996.23 (free base) | 25 MG
Ebiratide (HOE-427) TFA is an ACTH 4-9 derivative that acts directly on the central nervous system and exhibits memory-enhancing efficacy. It enhances acetycholine (ACh) metabolism in rat brain.
- ACTH 4-9 derivative
- Acts directly on the central nervous system
- Exhibits memory-enhancing efficacy
- Enhances acetylcholine (ACh) metabolism in rat brain
- Exhibits neuroprotective efficacy in electroconvulsive shock
- Exhibits anti-amnestic efficacy in Scopolamine (HY-N0296)-induced memory impairment in mice model
Apexbio Technology LLC DTP3 TFA 1809784-29-9 (free-base) 25mg
DTP3 TFA is a small-molecule inhibitor targeting the GADD45 /MKK7 protein-protein interaction complex It is designed to disrupt this interaction thereby modulating downstream NF- B signaling involved in tumor cell survival DTP3 TFA exerts its biological activity primarily by binding directly to MKK7 (KD 64 81 nM) inducing conformational changes that dissociate GADD45 from MKK7 resulting in activation of JNK signaling In cell-based studies DTP3 TFA selectively inhibits proliferation of cancer cell lines with elevated GADD45 expression Based on these pharmacological properties DTP3 TFA holds research potential in the study and therapeutic intervention of cancers including multiple myeloma via disruption of GADD45 /MKK7 signaling
Medchemexpress LLC PD1-PDL1-IN 1 TFA | 2005454-12-4 | >99.5% | 385.38 g/mol | C14H23N7O6 | 1 ML
PD1-PDL1-IN 1 TFA is a small-molecule programmed cell death 1 (PD-1) inhibitor supplied as the trifluoroacetic acid (TFA) salt for research use. It is intended for use as an immune-modulating reagent in PD-1/PD-L1 pathway studies, screening, and preclinical laboratory assays.
- Potent PD-1 inhibition useful for pathway and mechanism studies.
- Supplied as a TFA salt to aid solubility and handling.
- Characterized with published CAS and molecular data for identification.
- Suitable for compound screening and preclinical research applications.
- Available in small research-scale formats for laboratory use.
Medchemexpress LLC Cilengitide TFA | 199807-35-7 | 99.92% | 702.68 | 1 ML
Cilengitide is a potent and selective integrin inhibitor for αvβ3 and αvβ5 receptors, with IC50 values of 4 nM and 79 nM, respectively. It functions as an αvβ3 and αvβ5 integrin receptor antagonist. In cell adhesion studies, it inhibits integrin-mediated binding to vitronectin with IC50s of 0.4 and 0.4 μM in human melanoma M21 or UCLA-P3 human lung carcinoma cell lines. In vitro, concentrations greater than 1 μM show concentration- and time-dependent cytotoxic effects. In nude mice bearing M21-L melanoma tumors, it demonstrates inhibition of tumor growth with reductions in both tumor volume and tumor weight.
- Potent and selective integrin inhibitor for αvβ3 and αvβ5 receptors.
- Inhibits integrin-mediated binding to vitronectin.
- Exhibits cytotoxic effects in vitro at concentrations greater than 1 μM.
- Inhibits tumor growth in melanoma models.
Apexbio Technology LLC 2X hyperfusion plus master mix (With dye) 10X1ml
Our 2X Hyperfusion Plus Master Mix (With dye) product offers high fidelity strong amplification performance and faster extension speed simultaneously making it suitable for most PCR applications Hyperfusion Plus DNA Polymerase is created by fusing a Pyrococcus-like proofreading polymerase with a DNA binding domain providing increased fidelity and speed Hyperfusion Plus DNA Polymerase owns high fidelity 50 times lower error rate than Taq DNA Polymerase and 6 times lower error compared to Pyrococcus Furious DNA Polymerase Experimental results demonstrate that our Hyperfusion Plus polymerase can amplify genome fragments as long as 20 1 kb 2X Hyperfusion plus master mix (With dye) is a ready-to-use 2 premix solution containing polymerase dNTPs an already optimized buffer system and dye Our mix is ideal for any detection and the PCR product can be directly electrophoresed after the amplification without the need to add a loading buffer
Medchemexpress LLC L-Serine, L-alanyl-L-prolyl-L-prolyl-L-histidyl-L-alanyl-L-leucyl- (TFA) | 99.9% | 805.80 | 1 MG
RS 09 TFA is an LPS peptide mimic and a Toll-like Receptor 4 (TLR4) agonist. It can bind to TLR-4, activate NF-κB, and function as an adjuvant in vivo, enhancing the antigen-specific immune response.
- Stimulates TLR-4 and activates NF-κB in HEK-BLUETM-4 cells
- Induces nuclear translocation of NF-κB and secretion of inflammatory cytokines in RAW264.7 cells
- Used as an adjuvant to co-immunize BALB/c mice with specific antigens
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid | 76-05-1 | MFCD00004169 | 4 x 2 mL
Trifluoroacetic acid | Purity: 99% | Mol Wt: 114.02 | 76-05-1 | MFCD00004169 | 4 x 2 mL
Medchemexpress LLC Abaloparatide TFA | 99.5% | 4074.61 | 25 MG
Abaloparatide TFA | 99.5% | 4074.61 | 25 MG
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid ReagentPlus, 99, 76-05-1, MFCD00004169
Trifluoroacetic acid ReagentPlus, 99
Medchemexpress LLC Ceftolozane TFA 1mg | 1628046-32-1 | 1MG
Ceftolozane TFA is a cephalosporin antibiotic that can be used to inhibit Gram-negative bacterial infections Ceftolozane TFA can be used to synthesize new antibiotic that are more potent and safer[1
