Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC TP-5801 (TFA) | 99.6% | 641.48 | 25 MG
TP-5801 TFA is an orally active TNK1 (non-receptor tyrosine kinase) inhibitor with an IC50 of 1.40 nM. This compound demonstrates anti-tumor activity and is suitable for various research applications.
- Inhibits TNK1-driven, BCR-ABL-driven, and IL-3-driven Ba/F3 cell growth.
- Inhibits TNK1-dependent L540 cell growth at low nM levels.
- Shows efficacy in mouse survival models, significantly prolonging lifespan.
- Inhibits localized tumor growth in mouse xenograft models.
Medchemexpress LLC Lys-coenzyme A trifluoroacetate | 98.5% | 1108.82 g·mol⁻1 | C33H54F3N10O21P3S | 5 MG
Lys-CoA TFA is a bisubstrate-mimic inhibitor of the p300 histone acetyltransferase (HAT). It inhibits p300-dependent acetylation (reported IC50 = 50-500 nM) with >100-fold selectivity over PCAF and is intended for use in biochemical and cell-based studies probing p300-mediated acetylation.
- Selective p300 histone acetyltransferase (HAT) inhibitor (IC50 = 50-500 nM)
- Greater than 100-fold selectivity versus PCAF
- High purity (98.5%) suitable for research applications
- Molecular formula C33H54F3N10O21P3S
- Molecular weight 1108.82 g·mol⁻1
- Supplied as a small-quantity solid for biochemical assays and cell studies
Medchemexpress LLC MS9427 TFA | 98.4% | 1107.50 | 5 MG
MS9427 TFA is a potent PROTAC EGFR degrader that selectively targets and degrades mutant EGFR through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. This compound effectively inhibits the proliferation of NSCLC cells and shows antiproliferative activity against HCC-827 cells.
- Potent PROTAC EGFR degrader
- Selectively degrades mutant EGFR
- Utilizes ubiquitin/proteoteasome system and autophagy/lysosome pathways
- Inhibits proliferation of non-small cell lung cancer (NSCLC) cells
- Exhibits antiproliferative activity against HCC-827 cells
- Induces EGFRDel19 degradation
Medchemexpress LLC Tfllr-nh2(tfa) | 1313730-19-6 | 99.6% | 761.83 | 50 MG
TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM. It is for research use only and not sold to patients.
- Functions as a selective PAR1 agonist.
- Stimulates concentration-dependent increases in intracellular calcium.
- Modulates E-cadherin and vimentin expression in SW620 cells.
- Induces edema in rat paw models.
- Stimulates Evans blue extravasation in various mouse tissues.
- Exhibits both contraction and relaxation effects.
Medchemexpress LLC Ql9 tfa | 95.91% | 5 MG
QL9 (QLSPFPFDL) TFA is a high-affinity alloantigen for the 2C T cell receptor (TCR), intended for research use only.
- High-affinity alloantigen
- Specific for the 2C T cell receptor (TCR)
- Suitable for research applications
Medchemexpress LLC Mifamurtide (TFA) | 98.0% | 1351.52 | 1 MG
Mifamurtide TFA (MTP-PE TFA) is an analog of the muramyl dipeptide (MDP) that functions as a nonspecific immunomodulator by stimulating the immune response, activating macrophages and monocytes. It is a specific ligand for NOD2 and acts as an insulin sensitizer, with potential applications in rare disease and osteosarcoma research.
- Induces reduction of MG63 cell numbers when co-cultured with macrophages.
- Increases M1 polarization marker iNOS and M2 polarization marker CD206 mRNAs.
- Increases pro-inflammatory (IL-1β, IL-6) and anti-inflammatory (IL-4, IL-10) cytokines.
- Activates macrophages and monocytes, leading to upregulation of tumoricidal activity and secretion of pro-inflammatory cytokines.
- Shows a trend of diminished spontaneous lung metastasis dissemination in osteosarcoma models.
- Improves glucose tolerance during endotoxemia and in HFD-fed mice.
Medchemexpress LLC Iberiotoxin TFA | 99.4% | 4230.85 | 1 MG
Iberiotoxin (TFA) is a potent and selective inhibitor of high conductance Ca2+-activated K+ channels. This compound demonstrates high affinity for its target with a Kd of approximately 1 nM, and it specifically targets these channels without affecting other types of voltage-dependent ion channels.
- Selective inhibitor of high conductance Ca2+-activated K+ channels.
- High affinity with a Kd of ~1 nM.
- Does not block other types of voltage-dependent ion channels.
Medchemexpress LLC Myr-FEEERA-OH (TFA) | 990.15 | 25 MG
mP6 (Myr-FEEERA-OH) is a myristoylated peptide. It inhibits the interaction of Gα13 with integrin β3 without disrupting talin-dependent integrin function, and can block the GTP usage of Rac1, Rap1, and Rab7.
- Effectively inhibits the infection of CHO-A24 cells
- Myristoylated peptide
- Inhibits interaction of Gα13 with integrin β3
- Blocks GTP usage of Rac1, Rap1, and Rab7
Medchemexpress LLC Vasculotide TFA | 99.66% | 14000 (average) | 1 MG
Vasculotide TFA is an angiopoietin-1 mimetic that activates Tie-2, inducing its phosphorylation. It exhibits anti-inflammatory and anti-permeability effects, ameliorating endotoxin-induced endothelial barrier dysfunction and promoting angiogenesis in a mouse model of diabetic ulcer. It also protects mice from vascular leakage, reduces mortality in murine abdominal sepsis, and decreases microvascular leakage while improving microcirculatory perfusion in a rat model of hemorrhagic shock.
- Activates Tie-2 and induces its phosphorylation
- Exhibits anti-inflammatory and anti-permeability effects
- Promotes angiogenesis
- Protects against vascular leakage and reduces mortality in sepsis models
- Improves microcirculatory perfusion
- For research use only
Medchemexpress LLC TFLLR-NH2(TFA) | 1313730-19-6 | 99.6% | 761.83 | 10 MG
TFLLR-NH2(TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM, intended for research use. It stimulates concentration-dependent increases in intracellular calcium and promotes upregulation of E-cadherin expression in SW620 cells. In vivo, it can induce oedema and extravasation in various organs.
- Selective PAR1 agonist (EC50 of 1.9 μM)
- Induces concentration-dependent increases in intracellular calcium
- Upregulates E-cadherin expression in SW620 cells
- Stimulates secreted TGF-β1 in platelet cultures
- Can induce oedema and extravasation in animal models
- Stable for 2 years as powder at -80°C
- Stable for 6 months in solvent at -80°C
Medchemexpress LLC Damgo tfa | 950492-85-0 | 99.5% | 627.61 | 1 ML
DAMGO TFA is a selective μ-opioid receptor (μ-OPR) agonist, exhibiting a Kd of 3.46 nM for native μ-OPR. It significantly reduces the activation of neuronal Akt and ERK1/2 by CXCL12 and inhibits CXCL12-promoted neuronal survival without down-regulating CXCR4 protein expression. This compound also effectively inhibits the prostaglandin E2 (PGE2) induced increase in a tetrodotoxin-resistant voltage-gated Na+ current (TTX-R INa). In vivo studies show DAMGO TFA produces significant anti-injury and long-lasting analgesic effects in male Sprague-Dawley rats.
- Selective μ-opioid receptor agonist
- Exhibits Kd of 3.46 nM for native μ-OPR
- Reduces activation of neuronal Akt and ERK1/2
- Inhibits CXCL12-promoted neuronal survival
- Does not down-regulate CXCR4 protein expression
- Inhibits prostaglandin E2 induced increase in TTX-R INa
- Produces anti-injury effects
- Provides long-lasting analgesic effects
Medchemexpress LLC Α-MSH (TFA) | 171869-93-5 | 98.5% | 25 MG
α-MSH TFA (α-Melanocyte-Stimulating Hormone TFA) is an endogenous neuropeptide that acts as a melanocortin receptor 4 (MC4R) agonist. It exhibits anti-inflammatory and antipyretic activities, being a post-translational derivative of pro-opiomelanocortin (POMC).
- Modulates CNS inflammation by acting directly on melanocortin receptors in glial cells.
- Modulates NFκB activation.
- Inhibits translocation of transcription factor κB to the nucleus.
- Effectively modulates inflammatory reactions when given systemically.
Medchemexpress LLC 2H-Cho-Arg (TFA) | 1609010-59-4 | 99% | 886.06 | 1 MG
2H-Cho-Arg (TFA) is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection.
- Steroid-based cationic lipid
- Contains a 2H-cholesterol skeleton
- Coupled to an L-arginine head group
- Facilitates gene transfection
- Stable under recommended storage conditions
- For research use only
Medchemexpress LLC PSMA I&S TFA | 98.15% | 1413.43 | 5 MG
PSMA I&S (TFA) is a precursor of the 99mTc-labeled PSMA-targeting ligand, intended for research use only.
- Precursor of 99mTc-labeled PSMA-targeting ligand
- For research use only